Seamless Execution Across Early-Phase Alzheimer’s Trials

In the face of pandemic-era recruitment barriers and aggressive timelines, CRC partnered with a sponsor developing a novel Alzheimer’s treatment to support three early-phase trials—advancing the program from first-in-human (FIH) to long-term safety evaluation.

Across all three studies, CRC delivered consistent communication, high-touch site engagement, and trusted operational oversight to keep the program moving forward:

• Trial A: Phase I FIH study in healthy volunteers (47 subjects, 1 site)
• Trial B: Phase Ib/IIa study in Alzheimer’s patients (158 subjects, 18 sites)
• Trial C: Phase II OLE in rollover and de novo patients (121 subjects, 13 sites)

Despite compressed SAD/MAD timelines, turnover among vendor staff, and participant hesitations during COVID-19, CRC ensured on-time and on-budget completion—positioning the sponsor to move confidently into the next phase of development.

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